Caspase-2 is an upstream initiator of apoptosis signaling, specifically hydrolyzes the peptide substrate VDVAD-pNA (Val-Asp-Val-Ala-Asp-p-nitroanilide).
Caspases are a family of proteases involved in apoptosis, encompassing over ten members. Caspase-2, also known as Ich-1 or Nedd-2, is activated during apoptotic signaling. Caspase-2 mRNA has two distinct splice forms: the protein translated from the full-length mRNA promotes apoptosis, while the shortened protein product inhibits apoptosis. Caspase-2 can be activated by caspases 1 and 3, as well as granzyme B. Assay principle: Caspase-2 specifically hydrolyzes the peptide substrate VDVAD-pNA (Val-Asp-Val-Ala-Asp-p-nitroanilide), releasing free nitroanilide (pNA) with a maximum absorbance at 405 nm.
Caspase-2 Colorimetric Assay Kit provides a convenient and simple way for detecting the VDVAD-dependent caspase activity.
| 产品名称 | Caspase-2 Colorimetric Assay Kit |
|---|---|
| 中文名称 | 请咨询 |
| Cat No. 目录编号 | ABC-BR0077 |
| Product Type 产品类型 | Cell Biology Reagents（细胞生物学试剂） |
| 规格 | 20 T, 48 T, 96 T |
| 储存条件 | PartⅠ in 2-8℃, PartⅡ in -20℃. |
| 价格 | 价格请询价 |
| 文档名称 | 类型 | 语言 | 说明 |
|---|---|---|---|
| 产品说明书（Product Manual） | 中 / 英 | 含复溶、稀释、储存与使用操作说明 | |
| 质检报告（COA） | 英 | 按批次出具，随货提供 | |
| 安全数据表（MSDS） | 中 / 英 | 危险组分识别、防护措施与应急处置 |
