Recombinant Human, Mouse, Rat, Cynomolgus, Rhesus, Rabbit Activin A Protein

Activin protein is composed of two β subunits, βA βA (activin A), βB βB (activin B), or βA βB (activin AB), produced in many cell types and organs.

Activins are growth factors with multiple roles in the development and homeostasis. Activins are disulfide-linked homo- and heterodimers of four inhibin β chains, Activins A are homodimers formed from inhibin βA. Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins produced by many cell types throughout development. Activin-A initiates signaling by binding to a heteromeric complex of two type I and two type II serine/threonine kinase receptors. This binding activates the receptor kinases, leading to the phosphorylation of intracellular mediators SMAD2 and 3. These phosphorylated SMADs complex with SMAD4, translocate to the nucleus, and regulate gene expression.

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.